Studying the mechanical properties mismatching of SnSe₂/ZrS₂ 2D materials with Voigt-Reuss-Hill (VRH) schemes promise a novel structure for sensing applications. For the first time, we studied the effect of mechanical mismatching properties of SnSe₂/ZrS₂ multilayers with VRH schemes on the acoustic wave's propagation through acoustic superlattice (AS). We proposed [(SnSe₂/ZrS₂)⁴] superlattice with VRH schemes as a new THz multichannel sensor for acetonitrile sensing. The [(SnSe₂/ZrS₂)⁴] with Voigt scheme introduced several resonant peaks for acetonitrile inside the superlattice bandgap compared to Hill and Reuss schemes. The appropriate relation between resonance frequency shift and resonance bandwidth is the key to improving the multichannel sensor's sensitivity to liquid characteristics. Further, we studied the effect of low and high temperatures on our multichannel sensor. Furthermore, the highest sensitivity and resonance frequency were recorded by our AS with the Voigt scheme towards acetonitrile having values of 0.287 (GHz/(kg/m³)) and 0.237 THz at 0 °C. The results show a novel sensitivity of acetonitrile for low-temperature environments.