EJ
E.P.J. Jongkind
6 records found
1
Chiral amines are valuable compounds in the pharmaceutical industry. These valuable compounds have been made via organocatalysis, metallocatalysis but in the last two decades also via biocatalysis. Enzymes are highly selective, making them attractive catalysts to target chiral am
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Utilisation of fatty acids generally relies on pre-existing functional groups such as the carboxylate group or C=C-double bonds. Addition of new functionalities into the hydrocarbon part opens up new possibilities for fatty acid valorisation. In this contribution we demonstrate t
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Native amine dehydrogenases (nat-AmDHs) catalyze the (S)-stereoselective reductive amination of various ketones and aldehydes in the presence of high concentrations of ammonia. Based on the structure of CfusAmDH from Cystobacter fuscus complexed with Nicotinamide adenine dinucleo
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In this study, we developed a new bienzymatic reaction to produce enantioenriched phenylethanols. In a first step, the recombinant, unspecific peroxygenase from Agrocybe aegerita (rAaeUPO) was used to oxidise ethylbenzene and its derivatives to the corresponding ketones (prochira
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Access to chiral amines with more than one stereocentre remains challenging, although an increasing number of methods are emerging. Here we developed a proof-of-concept bi-enzymatic cascade, consisting of an ene reductase and amine dehydrogenase (AmDH), to afford chiral diastereo
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Producing chiral amines
A bi-enzymatic cascade involving Old Yellow Enzymes and amine dehydrogenases
Chiral amines are valuable compounds for their use as building blocks for pharmaceutical and fine chemical industries. Previously, chiral amines were made with metals as catalysts, but these are unsustainable and difficult to remove from the product. Organocatalysis is a sustaina
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