The last decade has witnessed the expansion of design space to include the epistemologies and methodologies of more-than-human design (MTHD). Design researchers and practitioners have been increasingly studying, designing for, and designing with nonhumans. This panel will bring together HCI experts who work on MTHD with different nonhumans as their subjects. Panelists will engage the audience through discussion of their shared and diverging visions, perspectives, and experiences, and through suggestions for opportunities and challenges for the future of MTHD. The panel will provoke the audience into reflecting on how the emergence of MTHD signals a paradigm shift in HCI and human-centered design, what benefits this shift might bring and whether MTH should become the mainstream approach, as well as how to involve nonhumans in design and research.