A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

Quiros Solano, W.F.; Gaio, N.; Silvestri, C.; Arik, Y.B.; Stassen, O.M.J.A.; van der Meer, A.D.; Bouten, C.V.C.; Van Den Berg, A.; Dekker, R.; Sarro, Pasqualina M

doi:10.1109/MEMSYS.2018.8346550

A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

Conference paper (2018)

Authors

W.F. Quiros Solano Electronic Components, Technology and Materials -

N. Gaio Electronic Components, Technology and Materials -

C. Silvestri Tera-Hertz Sensing -

Y.B. Arik University of Twente

O.M.J.A. Stassen Eindhoven University of Technology

A.D. van der Meer University of Twente

C.V.C. Bouten Eindhoven University of Technology

A. Van Den Berg University of Twente

R. Dekker Electronic Components, Technology and Materials -

Pasqualina M Sarro Electronic Components, Technology and Materials -

Research Group

Electronic Components, Technology and Materials () (TU Delft)

DOI: https://doi.org/10.1109/MEMSYS.2018.8346550

Silicon Fabrication Throughput Manuals Biomembranes Micromechanical devices Microchannels

To reference this document use:

http://resolver.tudelft.nl/uuid:df392e75-5fd0-4e1e-af54-8565dba7efb1

More Info

expand_more

Published Date

2018

Language

English

Reuse Rights

Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.

Faculty

Electrical Engineering, Mathematics and Computer Science

Department

Microelectronics

Research Group

Electronic Components, Technology and Materials

Abstract

We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on Lab-on-Chip (LOC) and Organ-on-Chip (OOC) devices. The use of silicon as carrier substrate and a water-soluble sacrificial layer allows a simple and reproducible transfer of the membranes to any PDMS-based OOC and LOC device. The use of IC and MEMS compatible techniques reduces significantly the fabrication time and the need of manual handling. Our method is suitable for automatic assembling systems, such as pick-and-place, crucial to significantly increase the throughput of OOC and LOC devices assembling. Membranes with 8 μm pore size and as thin as 4 μm are successfully transferred. The viability and biocompatibility of the transfer was assessed by culturing two different cell lines on an OOC with transferred porous PDMS membranes.

Files

08346550.pdf

(pdf | 0.796 Mb)

Unknown license