Design and Fabrication of a Soft Photonic Crystal Brain Implant

Abstract

A research gap exists in a targeted drug delivery into the brain with an implant placed on the outer surface of the cerebral cortex. If an implant with spatial control that can release drugs to a target location can be developed, it will provide efficient treatment opportunities for a variety of brain disorders such as strokes. One of the questions in realizing this implant is how to activate the drug release mechanism. Light is a promising activation stimulus due to its spatial precision and flexibility in the optical path. This thesis is a feasibility study into carrying light inside such a brain implant using a photonic crystal waveguide. Such a device must be soft and maintain its functionality during the mechanical bending imposed on the implant by the geometry and movement of the brain. A flexible 2D photonic crystal is simulated using COMSOL Multiphysics with the goal of designing a waveguide that functions with infrared light. The dispersion diagram of the photonic crystal is plotted to design for a bandgap at the operating wavelength. The transmission through a linear waveguide is calculated for the deformed state of the implant in mechanical bending, which is modeled as a 2D strain. A metallo-photonic crystal with photoresist nanopillars coated with a gold thin film and embedded in a flexible PDMS matrix is selected as the prototype for fabrication. The nanopillar arrays that form the photonic crystal waveguide are printed using two-photon polymerization (2PP), deposited with gold then transferred into photosensitive PDMS by drop casting. For characterization, a tapered rib waveguide is designed for light coupling and an optical end-fire test setup is built for transmission measurements on the fabricated device.