PL

PF Leadlay

8 records found

A polylinker approach to reductive loop swaps in modular polyketide synthases

Enantioselective synthesis of tetrasubstituted d-lactones.

Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues

Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a biomodular polyketide synthase.

The thioesterase of the erythromycin-producing polyketide synthase: influence of acyl chain structure on the mode of release of substrate analogues from the acyl enzyme intermediates.

Enantiospecific synthesis of tetrasubstituted delta-lactones.

Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension.

Rational engineering of complex polyketide biosynthesis - Where do we begin?.