A polylinker approach to reductive loop swaps in modular polyketide synthases

Synthesis of Prelactone B

Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues

Enantioselective synthesis of tetrasubstituted d-lactones.

Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a biomodular polyketide synthase.

Enantiospecific synthesis of analogues of the diketide intermediate of the erythromycin polyketide synthase (PKS).

The thioesterase of the erythromycin-producing polyketide synthase: influence of acyl chain structure on the mode of release of substrate analogues from the acyl enzyme intermediates.

Enantiospecific synthesis of tetrasubstituted delta-lactones.

Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension.

Rational engineering of complex polyketide biosynthesis - Where do we begin?.