Study Objectives: Despite frequent sleep disruption in the pediatric intensive care unit, bedside sleep monitoring in real time is currently not available. Supervised machine learning applied to electrocardiography data may provide a solution, because cardiovascular dynamics are directly modulated by the autonomic nervous system during sleep. Methods: This retrospective study used hospital-based polysomnography recordings obtained in noncritically ill children between 2017 and 2021. Six age categories were defined: 6–12 months, 1–3 years, 3–5 years, 5–9 years, 9–13 years, and 13–18 years. Features were derived in time, frequency, and nonlinear domain from preprocessed electrocardiography data. Sleep classification models were developed for 2, 3, 4, and 5 states using logistic regression, random forest, and XGBoost classifiers during 5-fold nested cross-validation. Models were additionally validated across age categories. Results: A total of 90 noncritically ill children were included with a median (Q1, Q3) recording length of 549.0 (494.8, 601.3) minutes. The 3 models obtained an area under the receiver operator characteristic curve of 0.72–0.78 with minimal variation across classifiers and age categories. Balanced accuracies were 0.70–0.72, 0.59–0.61, 0.50–0.51, and 0.41–0.42 for 2, 3, 4, and 5 states, respectively. Generally, the XGBoost model obtained the highest balanced accuracy (P < .05), except for 5 states for which logistic regression excelled (P = .67). Conclusions: Electrocardiography-based machine learning models are a promising and noninvasive method for automated sleep classification directly at the bedside of noncritically ill children aged 6 months–18 years. Models obtained moderate-to-good performance for 2- and 3-state classification.

STUDY OBJECTIVES: Although sleep is frequently disrupted in the pediatric intensive care unit, it is currently not possible to perform real-time sleep monitoring at the bedside. In this study, spectral band powers of electroencephalography data are used to derive a simple index for sleep classification. METHODS: Retrospective study at Erasmus MC Sophia Children's Hospital, using hospital-based polysomnography recordings obtained in non-critically ill children between 2017 and 2021. Six age categories were defined: 6-12 months, 1-3 years, 3-5 years, 5-9 years, 9-13 years, and 13-18 years. Candidate index measures were derived by calculating spectral band powers in different frequent frequency bands of smoothed electroencephalography. With the best performing index, sleep classification models were developed for two, three, and four states via decision tree and five-fold nested cross-validation. Model performance was assessed across age categories and electroencephalography channels. RESULTS: In total 90 patients with polysomnography were included, with a mean (standard deviation) recording length of 10.3 (1.1) hours. The best performance was obtained with the gamma to delta spectral power ratio of the F4-A1 and F3-A1 channels with smoothing. Balanced accuracy was 0.88, 0.74, and 0.57 for two-, three-, and four-state classification. Across age categories, balanced accuracy ranged between 0.83 and 0.92 and 0.72 and 0.77 for two- and three-state classification, respectively. CONCLUSIONS: We propose an interpretable and generalizable sleep index derived from single-channel electroencephalography for automated sleep monitoring at the bedside in non-critically ill children ages 6 months to 18 years, with good performance for two- and three-state classification. CITATION: van Twist E, Hiemstra FW, Cramer ABG, et al. An electroencephalography-based sleep index and supervised machine learning as a suitable tool for automated sleep classification in children. J Clin Sleep Med. 2024;20(3):389-397.

Background and Objectives Early neuroprognostication in children with reduced consciousness after cardiac arrest (CA) is a major clinical challenge. EEG is frequently used for neuroprognostication in adults, but has not been sufficiently validated for this indication in children. Using machine learning techniques, we studied the predictive value of quantitative EEG (qEEG) features for survival 12 months after CA, based on EEG recordings obtained 24 hours after CA in children. The results were confirmed through visual analysis of EEG background patterns. Methods This is a retrospective single-center study including children (0–17 years) with CA, who were subsequently admitted to the pediatric intensive care unit (PICU) of a tertiary care hospital between 2012 and 2021 after return of circulation (ROC) and were monitored using EEG at 24 hours after ROC. Signal features were extracted from a 30-minute EEG segment 24 hours after CA and used to train a random forest model. The background pattern from the same EEG fragment was visually classified. The primary outcome was survival or death 12 months after CA. Analysis of the prognostic accuracy of the model included calculation of receiver-operating characteristic and predictive values. Feature contribution to the model was analyzed using Shapley values. Results Eighty-six children were included (in-hospital CA 27%, out-of-hospital CA 73%). The median age at CA was 2.6 years; 53 (62%) were male. Mortality at 12 months was 56%; main causes of death on the PICU were withdrawal of life-sustaining therapies because of poor neurologic prognosis (52%) and brain death (31%). The random forest model was able to predict death at 12 months with an accuracy of 0.77 and positive predictive value of 1.0. Continuity and amplitude of the EEG signal were the signal parameters most contributing to the model classification. Visual analysis showed that no patients with a background pattern other than continuous with amplitudes exceeding 20 μV were alive after 12 months. Discussion Both qEEG and visual EEG background classification for registrations obtained 24 hours after ROC form a strong predictor of nonsurvival 12 months after CA in children.