System Design in the built environment is one of the most influential design paradigms in architecture and construction. This paper seeks to amalgamate empirical design strategies with various architectural principles, including the notion of “open buildings” or “open-ended architecture,” as well as Structuralism, all within a computational design framework employing discrete aggregation. Structuralism, articulated by Herman Herzberger, represents a “concept rather than a style” distinguishing the structure from the infill through individuality. It is important to note that the advanced technologies available for data collection and analysis did not exist during the 1960s Structuralist movement. Thus, this paper endeavours to forge a novel methodology, drawing inspiration from historical system design practices in architecture. The design research took place in the Merinterin Amsterdam due to its uniqueness and importance.