Epidemic forecasts are only as good as the accuracy of epidemic measurements. Is epidemic data, particularly COVID-19 epidemic data, clean, and devoid of noise? The complexity and variability inherent in data collection and reporting suggest otherwise. While we cannot evaluate the integrity of the COVID-19 epidemic data in a holistic fashion, we can assess the data for the presence of reporting delays. In our work, through the analysis of the first COVID-19 wave, we find substantial reporting delays in the published epidemic data. Motivated by the desire to enhance epidemic forecasts, we develop a statistical framework to detect, uncover, and remove reporting delays in the infectious, recovered, and deceased epidemic time series. Using our framework, we expose and analyze reporting delays in eight regions significantly affected by the first COVID-19 wave. Further, we demonstrate that removing reporting delays from epidemic data by using our statistical framework may decrease the error in epidemic forecasts. While our statistical framework can be used in combination with any epidemic forecast method that intakes infectious, recovered, and deceased data, to make a basic assessment, we employed the classical SIRD epidemic model. Our results indicate that the removal of reporting delays from the epidemic data may decrease the forecast error by up to 50%. We anticipate that our framework will be indispensable in the analysis of novel COVID-19 strains and other existing or novel infectious diseases.@en

Despite many studies on the transmission mechanism of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it remains still challenging to efficiently reduce mortality. In this work, we apply a two-population Susceptible-Infected-Removed (SIR) model to investigate the COVID-19 spreading when contacts between elderly and non-elderly individuals are reduced due to the high mortality risk of elderly people. We discover that the reduction of connections between two populations can delay the death curve but cannot reduce the final mortality. We propose a merged SIR model, which advises elderly individuals to interact less with their non-elderly connections at the initial stage but interact more with their non-elderly relationships later, to reduce mortality. Finally, immunizing elderly hub individuals can also significantly decrease mortality.

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Researchers from various scientific disciplines have attempted to forecast the spread of coronavirus disease 2019 (COVID-19). The proposed epidemic prediction methods range from basic curve fitting methods and traffic interaction models to machine-learning approaches. If we combine all these approaches, we obtain the Network Inference-based Prediction Algorithm (NIPA). In this paper, we analyse a diverse set of COVID-19 forecast algorithms, including several modifications of NIPA. Among the algorithms that we evaluated, the original NIPA performed best at forecasting the spread of COVID-19 in Hubei, China and in the Netherlands. In particular, we show that network-based forecasting is superior to any other forecasting algorithm.

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Complex systems are made up of many interconnected components. The interactions between components further produce emerging complex collective behaviors. In most cases, a complex system can be represented as a network in which the nodes represent the elements and the connected links illustrate the interactions. The spreading process is one of the most important dynamics in complex networks and systems. Since 2000, scientific findings related to spreading models and complex networks are experiencing a boom. Quantum computers are also complex systems. The development of quantum computing is to bring qualitative change to many fields by solving some problems faster than classical computers. However, during quantum computing, errors are spreading in the quantum circuits and accumulated with time...@en

We study a classical model for the accumulation of errors in multi-qubit quantum computations. By modeling the error process in a quantum computation using two coupled Markov chains, we are able to capture a weak form of time-dependency between errors in the past and future. By subsequently using techniques from the field of discrete probability theory, we calculate the probability that error quantities such as the fidelity and trace distance exceed a threshold analytically. The formulae cover fairly generic error distributions, cover multi-qubit scenarios, and are applicable to the randomized benchmarking protocol. To combat the numerical challenge that may occur when evaluating our expressions, we additionally provide an analytical bound on the error probabilities that is of lower numerical complexity. Besides this, we study a model describing continuous errors accumulating in a single qubit. Finally, taking inspiration from the field of operations research, we illustrate how our expressions can be used to decide how many gates one can apply before too many errors accumulate with high probability, and how one can lower the rate of error accumulation in existing circuits through simulated annealing.

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At the moment of writing, the future evolution of the COVID-19 epidemic is unclear. Predictions of the further course of the epidemic are decisive to deploy targeted disease control measures. We consider a network-based model to describe the COVID-19 epidemic in the Hubei province. The network is composed of the cities in Hubei and their interactions (e.g., traffic flow). However, the precise interactions between cities is unknown and must be inferred from observing the epidemic. We propose the Network-Inference-Based Prediction Algorithm (NIPA) to forecast the future prevalence of the COVID-19 epidemic in every city. Our results indicate that NIPA is beneficial for an accurate forecast of the epidemic outbreak.

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Dynamical processes running on different networks behave differently, which makes the reconstruction of the underlying network from dynamical observations possible. However, to what level of detail the network properties can be determined from incomplete measurements of the dynamical process is still an open question. In this paper, we focus on the problem of inferring the properties of the underlying network from the dynamics of a susceptible-infected-susceptible epidemic and we assume that only a time series of the epidemic prevalence, i.e., the average fraction of infected nodes, is given. We find that some of the network metrics, namely those that are sensitive to the epidemic prevalence, can be roughly inferred if the network type is known. A simulated annealing link-rewiring algorithm, called SARA, is proposed to obtain an optimized network whose prevalence is close to the benchmark. The output of the algorithm is applied to classify the network types.@en