SF

S. Folestad

6 records found

For dry powder inhaled formulations, good flow behaviour is vital in re-dispersing the powder. However, inhaled drug powders with a particle size below 10 µm are classified as highly cohesive materials with poor flow characteristics. Here we demonstrate how to alter the flow prop ...
Fluidization of cohesive pharmaceutical powders is difficult to achieve and typically requires the introduction of external forces. This study investigates the fluidization of the fine inhalation grade of lactose powders (size range from 0.1-20 μm) that are specifically developed ...
The wettability of pharmaceuticals is a key physical property which influences their dissolution rate, dispersibility, flowability and solid-state stability. Here, we provide a platform of surface nanoengineering methods capable of tuning the wettability of drug powders from high ...
In this work, we report molecular layer deposition (MLD) of ultrathin poly(ethylene terephthalate) (PET) films on gram-scale batches of ultrafine particles for the first time. TiO2 P25 nanoparticles (NPs) are coated up to 50 cycles in an atmospheric-pressure fluidized-bed reactor ...
The morphology, size, and surface properties of pharmaceutical particles form an essential role in the therapeutic performance of active pharmaceutical ingredients (APIs) and excipients as constituents in various drug delivery systems and clinical applications. Recent advances in ...
Atomic layer deposition on pharmaceutical particles for drug delivery applications is demonstrated using assisted fluidized bed dry powder processing. Complete and conformal layering is achieved on particle sizes from the lower micron to upper nanometer range under near ambient c ...