Atomic scale surface engineering of micro- to nano-sized pharmaceutical particles for drug delivery applications

Journal article (2017)

Authors

D. Zhang AstraZeneca
M. J. Quayle AstraZeneca
Gunilla Petersson AstraZeneca
J.R. van Ommen ChemE/Product and Process Engineering - AS
Staffan Folestad AstraZeneca
Research Group
ChemE/Product and Process Engineering (AS) (TU Delft)
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Published Date

28-08-2017

Language

English

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Faculty

Applied Sciences

Department

ChemE/Chemical Engineering

Research Group

ChemE/Product and Process Engineering

Abstract

Atomic layer deposition on pharmaceutical particles for drug delivery applications is demonstrated using assisted fluidized bed dry powder processing. Complete and conformal layering is achieved on particle sizes from the lower micron to upper nanometer range under near ambient conditions. As few as 2-14 atomic alumina layers alter particle properties: dissolution, dispersibility and heat transfer.

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