A robust chemo-enzymatic lactone synthesis using acyltransferase from Mycobacterium smegmatis

Drozdz, A.; Hanefeld, U.; Szymańska, K.; Jarzȩbski, A.; Chrobok, A.

A robust chemo-enzymatic lactone synthesis using acyltransferase from Mycobacterium smegmatis

Journal article (2016)

Authors

A. Drozdz Silesian University of Technology

U. Hanefeld BT/Biocatalysis -

K. Szymańska Silesian University of Technology

A. Jarzȩbski Polish Academy of Sciences, Silesian University of Technology

A. Chrobok Silesian University of Technology

Research Group

BT/Biocatalysis () (TU Delft)

Hydrogen peroxide Baeyer-Villiger oxidation Acyltransferase Lactones

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Published Date

2016

Language

English

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Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

The new application of acyltransferase, isolated from Mycobacterium smegmatis for the chemo-enzymatic Baeyer-Villiger oxidation of cyclic ketones to lactones was demonstrated. Acyltransferase exhibited high activity, and high stability under harsh reaction conditions, like oxidation with 60% aq. H₂O₂ at 45°C. This paves the way to a novel robust chemo-enzymatic method for lactone synthesis with high yields.