Peroxygenase-Catalysed Selective Oxidation of Silanes to Silanols

Journal article (2023)

Authors

X. Xu BT/Biocatalysis - AS
J.M.A. van Hengst BT/Biocatalysis - AS
Yejia Mao Student
Mireia Martinez Barcelona Supercomputing Center
Sergi Roda Barcelona Supercomputing Center
Martin Floor Barcelona Supercomputing Center
Victor Guallar Catalan Institution for Research and Advanced Studies (ICREA), Barcelona Supercomputing Center
C.E. Paul BT/Biocatalysis - AS
Miguel Alcalde Institute of Catalysis, CSIC, Madrid
F. Hollmann BT/Biocatalysis - AS
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2023 X. Xu, J.M.A. van Hengst, Yejia Mao, Mireia Martinez, Sergi Roda, Martin Floor, Victor Guallar, C.E. Paul, Miguel Alcalde, F. Hollmann
DOI: https://doi.org/10.1002/anie.202302844
More Info
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Published Date

2023

Language

English

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

A peroxygenase-catalysed hydroxylation of organosilanes is reported. The recombinant peroxygenase from Agrocybe aegerita (AaeUPO) enabled efficient conversion of a broad range of silane starting materials in attractive productivities (up to 300 mM h−1), catalyst performance (up to 84 s−1 and more than 120 000 catalytic turnovers). Molecular modelling of the enzyme-substrate interaction puts a basis for the mechanistic understanding of AaeUPO selectivity.