Grand Research Challenges for Sustainable Industrial Biotechnology

Review (2019)

Authors

A.J.J. Straathof BT/Bioprocess Engineering
S.A. Wahl OLD BT/Cell Systems Engineering
Kirsten Benjamin Amyris Inc
Ralf Takors University of Stuttgart
Nick Wierckx Forschungszentrum Jülich
Henk J. Noorman BT/Bioprocess Engineering, DSM
Research Group
BT/Bioprocess Engineering
Copyright: © 2019 Adrie J.J. Straathof, S.A. Wahl, Kirsten R. Benjamin, Ralf Takors, Nick Wierckx, H.J. Noorman
DOI: https://doi.org/10.1016/j.tibtech.2019.04.002
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Published Date

2019

Language

English

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Research Group

BT/Bioprocess Engineering

Abstract

Future manufacturing will focus on new, improved products as well as on new and enhanced production methods. Recent biotechnological and scientific advances, such as CRISPR/Cas and various omic technologies, pave the way to exciting novel biotechnological research, development, and commercialization of new sustainable products. Rigorous mathematical descriptions of microbial cells and consortia thereof will enable deeper biological understanding and lead to powerful in silico cellular models. Biological engineering, namely model-based design together with synthetic biology, will accelerate the construction of robust and high-performing microorganisms. Using these organisms, and ambitions towards zero-concepts with respect to emissions and excess resources in bioprocess engineering, industrial biotechnology is expected to become highly integrated into sustainable generations of technology systems.

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