The ability to control the motion of mechanical systems through interaction with light has opened the door to a plethora of applications in fundamental and applied physics. With experiments routinely reaching the quantum regime, the focus has now turned towards creating and exploiting interesting non-classical states of motion and entanglement in optomechanical systems. Quantumness has also shifted from being the very reason why experiments are constructed to becoming a resource for the investigation of fundamental physics and the creation of quantum technologies. Here, by focusing on opto- and electromechanical platforms we review recent progress in quantum state preparation and entanglement of mechanical systems, together with applications to signal processing and transduction, quantum sensing and topological physics, as well as small-scale thermodynamics.