The future of reliability is bright as each electronics company is spending 1–5% of their annual sales on cost of non-quality. These costs are related to product failures prior to the end of its warranty period. If even a portion of these costs are reduced, it would result in a substantial profit increase. Progress in the area of reliability can be found in five directions; (i) multi-scale and multi-physics simulations for physics of degradation; (ii) AI-based control systems in advanced production; (iii) smart sensoring and big data analysis; (iv) reliable materials and reliability testing; and (v) prognostics and health management/digital twin for condition monitoring. In this chapter, we discuss these directions and what it would mean for the future developments of the reliability domain.