Suppose X is a multidimensional diffusion process. Assume that at time zero the state of X is fully observed, but at time 0$ ]]> only linear combinations of its components are observed. That is, one only observes the vector for a given matrix L. In this paper we show how samples from the conditioned process can be generated. The main contribution of this paper is to prove that guided proposals, introduced in [35], can be used in a unified way for both uniformly elliptic and hypo-elliptic diffusions, even when L is not the identity matrix. This is illustrated by excellent performance in two challenging cases: a partially observed twice-integrated diffusion with multiple wells and the partially observed FitzHugh-Nagumo model.

Recently, there have been conceptually new developments in Monte Carlo methods through the introduction of new MCMC and sequential Monte Carlo (SMC) algorithms which are based on continuous-time, rather than discrete-time, Markov processes. This has led to some fundamentally new Monte Carlo algorithms which can be used to sample from, say, a posterior distribution. Interestingly, continuous-time algorithms seem particularly well suited to Bayesian analysis in big-data settings as they need only access a small sub-set of data points at each iteration, and yet are still guaranteed to target the true posterior distribution. Whilst continuous-time MCMC and SMC methods have been developed independently we show here that they are related by the fact that both involve simulating a piecewise deterministic Markov process. Furthermore, we show that the methods developed to date are just specific cases of a potentially much wider class of continuous-time Monte Carlo algorithms.We give an informal introduction to piecewise deterministic Markov processes, covering the aspects relevant to these new Monte Carlo algorithms, with a view to making the development of new continuoustime Monte Carlo more accessible. We focus on how and why sub-sampling ideas can be used with these algorithms, and aim to give insight into how these new algorithms can be implemented, and what are some of the issues that affect their efficiency.

Piecewise Deterministic Monte Carlo algorithms enable simulation from a posterior distribution, whilst only needing to access a sub-sample of data at each iteration. We show how they can be implemented in settings where the parameters live on a restricted domain.

In Turitsyn, Chertkov and Vucelja [Phys. D 240 (2011) 410-414] a nonreversible Markov Chain Monte Carlo (MCMC) method on an augmented state space was introduced, here referred to as Lifted Metropolis-Hastings (LMH). A scaling limit of the magnetization process in the Curie-Weiss model is derived for LMH, as well as for Metropolis-Hastings (MH). The required jump rate in the high (supercritical) temperature regime equals n^1/2 for LMH, which should be compared to n for MH. At the critical temperature, the required jump rate equals n^3/4 for LMH and n^3/2 for MH, in agreement with experimental results of Turitsyn, Chertkov and Vucelja (2011). The scaling limit of LMH turns out to be a nonreversible piecewise deterministic exponentially ergodic "zig-zag" Markov process.