Philippe Nghe
4 records found
1
Authored
The limits of evolution have long fascinated biologists. However, the causes of evolutionary constraint have remained elusive due to a poor mechanistic understanding of studied phenotypes. Recently, a range of innovative approaches have leveraged mechanistic information on reg ...
Stochasticity in cellular metabolism and growth
Approaches and consequences
Advances in our ability to zoom in on single cells have revealed striking heterogeneity within isogenic populations. Attention has so far focussed predominantly on underlying stochastic variability in regulatory pathways and downstream differentiation events. In contrast, the ...
Sign epistasis is a central evolutionary constraint, but its causal factors remain difficult to predict. Here we use the notion of parameterised optima to explain epistasis within a signalling cascade, and test these predictions in Escherichia coli. We show that sign epistasis ...