A.W. van der Vaart
17 records found
1
Authored
We obtain rates of contraction of posterior distributions in inverse problems with discrete observations. In a general setting of smoothness scales we derive abstract results for general priors, with contraction rates determined by discrete Galerkin approximation. The rate dep ...
Posterolateral or Direct Lateral Surgical Approach for Hemiarthroplasty After a Hip Fracture
A Randomized Clinical Trial Alongside a Natural Experiment
Importance: Hip fractures in older adults are serious injuries that result in disability, higher rates of illness and death, and a substantial strain on health care resources. High-quality evidence to improve hip fracture care regarding the surgical approach of hemiarthroplast ...
Posterolateral or direct lateral approach for cemented hemiarthroplasty after femoral neck fracture (APOLLO)
Protocol for a multicenter randomized controlled trial with economic evaluation and natural experiment alongside
Background and purpose — The posterolateral and direct lateral surgical approach are the 2 most common surgical approaches for performing a hemiarthroplasty in patients with a hip fracture. It is unknown which surgical approach is preferable in terms of (cost-)effectiveness an ...
The features in a high-dimensional biomedical prediction problem are often well described by low-dimensional latent variables (or factors). We use this to include unlabeled features and additional information on the features when building a prediction model. Such additional fe ...
A common task in quality control is to determine a control limit for a product at the time of release that incorporates its risk of degradation over time. Such a limit for a given quality measurement will be based on empirical stability data, the intended shelf life of the pro ...
The Pitman-Yor process is a random probability distribution, that can be used as a prior distribution in a nonparametric Bayesian analy-sis. The process is of species sampling type and generates discrete distribu-tions, which yield of the order nσ different values ( ...
Discrimination between potentially immunogenic protein aggregates and harmless pharmaceutical components, like silicone oil, is critical for drug development. Flow imaging techniques allow to measure and, in principle, classify subvisible particles in protein therapeutics. How ...
In Memoriam Kobus Oosterhoff (1933–2015)
Statistics as both a purely mathematical activity and an applied science
We consider nonparametric estimation of the Lévy measure of a hidden Lévy process driving a stationary Omstein-Uhlenbeck process which is observed at discrete time points. This Lévy measure can be expressed in terms of the canonical function of the stationary distribution of t ...