Water, energy, and food resources are closely related in the water-energy-food (WEF) nexus, a tightly connected system in which impacts in one sector leads to changes in the other sectors. The WEF nexus approach studies these interactions to better understand their connections and implications across sectors, and is focused on making research practicable for policy. There is a clear lack of policy coherence studies to provide practical recommendations to achieve integrated resources management. This is true in the Tana River Basin (TRB), which provides abundant water, energy and food resources to the national economy and development of Kenya. This work carried out a WEF policy coherence assessment of the Tana River Basin. Results show that there are synergies and trade-offs across all resources sectors and their policy objectives. Water policies (e.g. to secure water availability) are generally evaluated as win-win, thus being supportive of attainment of goals in other policy sectors. Food policies (e.g. to develop the agricultural sector) show the highest number of trade-offs, suggesting these policies could be redesigned to minimise the trade-offs with other resource policies. This work highlights specifically which policies are relatively more or less supportive for holistic resources management in the TRB. In particular, the only TRB-level policy analysed (which is cross-resource in its ambition) shows synergies with national policy, offering opportunity for leveraging benefits and increasing implementation efficiency across resources. Strengthened cross-sectoral collaboration, joint workshops, and the establishment of a national cross-sectoral taskforce to develop aligned policies are recommended. This work provides a basis for similar studies across Africa, and promotes research that is of practical relevance.