Homogeneous Low-Crested Structures (HLCS) with pre-cast concrete units are a new coastal structure to protect beaches from wave attack. HLCS are a natural based solution which can be used to restore degraded coral reefs areas where not only the coastal protection is important but also the regeneration of the ecosystem. The placement grid of HLCS plays a relevant role on their hydraulic performance affecting the wave transmission and hydraulic stability. Within the Project HOLOBREAK, 5-layer Cubipod HLCS trunks with H/V≈2:1 were tested in the wave flume of the Laboratory of Ports and Coasts (30 x 1.2 x 1.2 m) at the Universitat Politècnica de València. The 5-layer Cubipod HLCS was constructed following a triangular equilateral placement grid with porosity p[%]=50 on a 4% bottom slope. The model showed a total height around 20 cm with Cubipods with nominal diameter D_n[cm]=3.79 In total, 100 tests were carried out with four wave steepnesses (s_0p=0.01, 0.02, 0.03 and 0.04) and four crest freeboards (R_c[cm]=-3, 0, 5, 10 cm). The tests measured the layer thickness, armor stability, wave reflection and wave transmission of the structure. The wave height (H_m0) and wave period (T_p) at the toe of the structure were obtained using the SwanOne model. In this study, Neural Network models are used to create a new wave transmission estimator valid for 5-layer Cubipod HLCS with R²=0.91 within the ranges-2<R_c/H_m0<3.6 and 0.008<s_0p<0.035.