In this paper, the effect of interface properties on the compressive failure behavior of 3D woven composites (3DWC) is investigated by incorporating a micromechanics-based multiscale damage model (MMDM). The correlation between the mesoscopic stress of yarns and microscopic stress of constituents is established by defining a stress amplification factor. With the microscopic stresses, the fiber breakage and matrix failure can be separately evaluated at the microscale, without assuming the yarns as transversely isotropic homogeneous materials. Especially, the interfacial debonding between yarns and matrix is also a dominant damage mode within 3DWC. Given that there is still a lack of studies on the influence of interfacial properties on the compressive failure behavior of 3DWC, it is meaningful to perform numerical parametric studies to reveal how the interface properties contribute to the damage mechanisms of 3DWC under compressions. The predicted results indicate that with the increase of interface strengths and fracture toughness, the compressive resistance of 3DWC can be significantly improved, resulting in higher strength and failure strain. Additionally, the studied 3DWCs with weak, medium and strong interfaces exhibit different damage development processes.