In recent years, prognostics gained attention in various industries by optimizing maintenance, boosting operational efficiency, and preventing costly downtime. Central to prognostics is the Remaining Useful Life (RUL), representing the critical time before system failure. Deep learning advancements facilitate RUL forecasting by extracting features from diverse data formats such as time series, images, or sequences thereof, in one, two, or three dimensions, respectively. Yet, predicting RUL from image sequences often relies heavily on resource-intensive techniques like digital image correlation, complicating data acquisition. To address challenges with high-dimensional data and unreliable models, this study introduces ISTRUST, an innovative Transformer-based architecture. ISTRUST (Interpretable Spatiotemporal TRansformer for Understanding STructures) tackles the dual challenges posed by high-dimensional data and the black-box nature of existing models. Leveraging Transformers’ attention mechanism, ISTRUST breaks down the spatiotemporal domain, effectively realizing interpretable RUL predictions under uncertainty using only sparse raw image sequences as input. Evaluated on fatigue-loaded composite samples showcasing crack propagation, ISTRUST interprets the relation between cracks and RUL via the attention mechanism. The results substantiate its capacity to interpret and clarify instances in which predictions may exhibit variability in accuracy. Through the attention mechanism, a strong correlation between the model’s spatiotemporal focus and the RUL predictions is established, making it, to the best of our knowledge, the first model to provide interpretable stochastic RUL predictions directly from sequential images of this nature.@en