Meso-scale conformational changes in Rad50/Mre11 upon DNA binding: implications for DNA tethering

The coiled-coil of the human Rad50 DNA repair protein contains specific segments of increased flexibility

Inhomogeneous flexibility of an intra-molecular coiled-coil structure in Rad50 measured with AFM

Human Rad50/Mre11 is a flexible complex that can tether DNA ends.