This chapter introduces an interdisciplinary perspective to investigate the transition process and to identify empirical evidence of social-ecological tipping points (SETPs) in the case studies on coal and carbon intensive regions (CCIRs) analyzed in the project TIPPING+. The interdisciplinary lens considers different modes of thought, frameworks, and multiple perspectives and interests from diverse stakeholders, a systems’ understanding, and different culture considerations across the CCIRs. Within this interdisciplinary process, we applied various lenses to study the potential for SETPs by combining insights from human geography, social psychology, regional socio-technical systems, and political economy perspectives on the phases of low carbon transitions and on the justice component of the transitions. Subsequently, this chapter gives an overview of how the eight CCIRs case studies in this book have applied various interdisciplinary lenses to investigate the regional transition and the emergence of SETPs.