This work examines the control of cross-flow instabilities (CFIs) and laminar–turbulent transition on a swept wing, through the plasma-based base flow modification (BFM) technique. The effect of experimentally derived plasma body forces on the steady boundary layer base flow is explored through numerical simulations. Linear stability theory is subsequently used to predict the net BFM effect on CFIs. Based on these preliminary predictions, experiments are conducted in a low-turbulence wind tunnel where a spanwise-invariant plasma actuator is installed near the wing leading edge and operated at constant input voltage and frequency. Various flow parameters governing the plasma-based BFM technique are investigated, namely the Reynolds number, angle of attack and wavelength of excited stationary CFI modes. Stationary and travelling CFIs are quantified by planar particle image velocimetry while the transition topology and location are recorded by infrared thermography. The results confirm the stabilising effect of BFM on the swept-wing boundary layer. However, the plasma-based BFM is found to render the boundary layer more susceptible to travelling CFIs. In the presence of both net BFM effect and intrinsic plasma unsteady perturbations, the plasma-based BFM technique achieves transition delay with specific combinations of Reynolds number, angle of attack and wavelength of excited stationary CFI modes. The present findings provide insights into the fundamental principles of operating plasma actuators within the context of BFM control.@en