The lack of effective place-making strategies to transform industrial urban areas into mixed-use areas, and the limited knowledge of how manufacturers interact with other actors, have exposed the vulnerability to future challenges of these redevelopment processes. Therefore, this research aims to identify directions of place-making strategies to overcome future challenges in the redevelopment of industrial urban areas, through the interaction of actors in the case of Schieoevers Noord. This is done following a research by design with a qualitative approach through the analysis of the case and its arenas of interaction, the exploration of possible future scenarios, and the identification of opportunities and challenges. This reveals opportunities to build on good relationships, promote co-creation, facilitate discussion and interaction, stimulate long-term investment and commitment, and develop awareness of existing businesses. However, challenges are portrayed in the dependence of private land ownership and public support for businesses development, the urge for space availability and affordability, and the lack of operation awareness between neighbors. Hence, it is possible to recommend that place-making strategies should be implemented in a timely manner, within the relevant arena and involving the respective actors. Within industrial urban areas, it is essential to activate businesses to exploit positive interests and prevent place-breakers, while unlocking new opportunities to implement strategies that facilitate community engagement and socio-economic interaction. The implementation of strategies over all of the arenas can enhance the effectiveness to overcome future challenges in the redevelopment of these areas.