In this study a novel structure for time-delay MIMO systems controller design is introduced. In this method decoupled Smith predictor (SP) controller is designed using Internal Model Control structure (IMC). In order to approximate decoupled system, step response model approximation is employed and simulated on MIMO multiple time-delay system. Moreover, to improve system performance from overshoot and rise time perspective, Smith predictor controller is combined with PI+CI structure. Furthermore, to increase system robustness, a low pass filter is designed. Afterwards, the proposed structure is applied to the model of a time-delay MIMO distillation tower system and obtained results are compared to those of a PID controller. Finally, performance of different design methods is evaluated using Integral error criterion (Integral Square Error criterion).@en