IM
Ian J. MacRae
3 records found
1
Argonaute proteins are the central effectors of RNA-guided RNA silencing pathways in eukaryotes, playing crucial roles in gene repression and defense against viruses and transposons. Eukaryotic Argonautes are subdivided into two clades: AGOs generally facilitate miRNA- or siRNA-m
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Author Correction
MRNA structural dynamics shape Argonaute-target interactions (Nature Structural & Molecular Biology, (2020), 27, 9, (790-801), 10.1038/s41594-020-0461-1)
In the version of this article initially published, the data in Fig. 6h and Extended Data Fig. 6j were incorrect due to errors in the simulation code. The correct figures are shown below. The Fig. 6h caption has been updated to “Arrows indicate unmasking time of the best fit.”, a
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Small interfering RNAs (siRNAs) promote RNA degradation in a variety of processes and have important clinical applications. siRNAs direct cleavage of target RNAs by guiding Argonaute2 (AGO2) to its target site. Target site accessibility is critical for AGO2-target interactions, b
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