The environmental crisis demands for an interdisciplinary design of urban infrastructure to increase resilience to climate change. Interdisciplinary design is about integration of data, concepts, ambitions and goals by bridging instrumental differences between engineering and spatial design. This paper presents the results of an interdisciplinary design study that deals with persistent flood issues in the Venice lagoon (Italy). The study illustrates how the differences in languages, methods and tools of the disciplines can be overcome by interdisciplinary collaboration directed towards the designing of spatial and technical solutions. Two design proposals are instrumentally described through the lens of the Casco and the Open Building concepts; both advocate the creation of an overarching frame as the basic condition for adaptive design. The paper gives insights on how to cooperate in interdisciplinary design settings in educational environments and builds knowledge on the collaboration between fields that might be relevant also for professional figures.@en