The control efficacy of classical periodic forcing and deep reinforcement learning (DRL) is assessed for a turbulent separation bubble (TSB) at Reτ=180 on the upstream region before separation occurs. The TSB can resemble a separation phenomenon naturally arising in wings, and a successful reduction of the TSB can have practical implications in the reduction of the aviation carbon footprint. We find that the classical zero-net-mas-flux (ZNMF) periodic control is able to reduce the TSB by 15.7%. On the other hand, the DRL-based control achieves 25.3% reduction and provides a smoother control strategy while also being ZNMF. To the best of our knowledge, the current test case is the highest Reynolds-number flow that has been successfully controlled using DRL to this date. In future work, these results will be scaled to well-resolved large-eddy simulation grids. Furthermore, we provide details of our open-source CFD–DRL framework suited for the next generation of exascale computing machines.@en