The efficacy of endovascular therapy in large vessel occlusion (LVO) of the anterior circulation is dependent to a high degree on the selection of patients who are likely to benefit from this procedure. To this end, functional outcome prediction based on clinical parameters is an active area of research. In the preoperative screening of LVO patients, CT-Angiography (CTA) imaging is commonly acquired. We compare the functional outcome prediction performance of multiple deep learning based classifiers with multiple conventional methods, including the clinically validated MR PREDICTS decision tool. Using a dataset composed of 1929 preprocedural CTA images combined with clinical data, we compare a clinical baseline model with an imaging based pipeline and a combined pipeline. For the imaging model backbone we train various state-of-the-art architectures (Med3D, Vision Transformer, Voxel Transformer). These models are used to predict dichotomized modified Rankin Scale score 90 days after mechanical thrombectomy. Binary classifier outcomes are quantified using Area-Under the receiver operating characteristic Curve (AUC). The activation maps of the best performing image based model are further investigated using the GradCAM++ posthoc visualization method. Combining clinical features with information extracted from CTA images does not significantly improve the performance of functional outcome prediction methods compared to the baseline model. The information extracted from the images does not seem to
be complementary to the clinical features. This multimodal technique can however replace radiologically derived biomarkers, as its performance is non-inferior.