Radiofrequency Pulse Design for Robust Quantitative Spin-Lock MRI

Doctoral thesis (2024)

Authors

C. Coletti ImPhys/Computational Imaging - AS , ImPhys/Weingärtner group - AS
Research Group
ImPhys/Weingärtner group (AS) (TU Delft)
More Info
expand_more

Published Date

2024

Language

English

Reuse Rights

Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.

Faculty

Applied Sciences

Department

ImPhys/Imaging Physics

Research Group

ImPhys/Weingärtner group

Abstract

Magnetic resonance imaging (MRI) is one of the most powerful tools currently available for diagnostic imaging and medical research. MRI can provide information about the composition, structure, and function of biological tissues and systems in a non-invasive way, with unsurpassed soft-tissue contrast and spatial resolution. While MRI images typically depict qualitative information, quantitative MRI techniques have emerged for their promise of enabling objective and intra-and inter-subject comparable quantification of tissue properties. Quantitative MRI techniques yield parametric maps, which are voxel-wise representations of physical properties of tissues, such as relaxation times. MRI relaxation times, conventionally T1 and T2, characterize the evolution of the excited MRI signal back to its equilibrium value and they are directly influenced by the molecular environment. Thus, T1 and T2 parametric maps yield useful insight into the normal state of biological tissues and eventual pathological remodeling.