Natural deep eutectic solvents as performance additives for biocatalysis

Book chapter (2021)

Authors

Özlem Erol Universiteit Leiden
F. Hollmann BT/Biocatalysis - AS
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2021 Özlem Erol, F. Hollmann
DOI: https://doi.org/10.1016/bs.abr.2020.09.004
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Published Date

2021

Language

English

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Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

Following ionic liquids, (natural) deep eutectic solvents ((NA)DES) are receiving significant attention as performance additives for biocatalytic reactions. (NA)DES are increasingly evaluated as solvents to replace water in hydrolase-catalyzed esterification reactions thereby shifting the reaction equilibrium. They also frequently outperform water in terms of solubility properties of hydrophobic reagents and thereby enable higher space-time yields. Furthermore, (NA)DES frequently exceed stabilizing effects on enzymes and thereby enable more robust (and therefore economically more attractive) biocatalytic syntheses. In this contribution, we will summarize and critically evaluate the recent literature on (NA)DES-supported biocatalysis.

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