Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale

Journal article (2020)

Authors

G.T. Höfler BT/Biocatalysis - AS
A. But BT/Biocatalysis - AS
S.H.H. Younes BT/Biocatalysis - AS , Sohag University
Ron Wever Universiteit van Amsterdam
C.E. Paul BT/Biocatalysis - AS
I.W.C.E. Arends Universiteit Utrecht
F. Hollmann BT/Biocatalysis - AS
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2020 G.T. Höfler, A. But, S.H.H. Younes, Ron Wever, C.E. Paul, I.W.C.E. Arends, F. Hollmann
DOI: https://doi.org/10.1021/acssuschemeng.9b07494
More Info
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Published Date

2020

Language

English

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.