Construction of correlation networks with explicit time-slices using time-lagged, variable interval standard and partial correlation coefficients

Meuleman, W.; Welten, MCM; Verbeek, FJ

Construction of correlation networks with explicit time-slices using time-lagged, variable interval standard and partial correlation coefficients

Conference paper (2006)

Authors

W. Meuleman

MCM Welten External organisation

FJ Verbeek External organisation

To reference this document use:

http://resolver.tudelft.nl/uuid:6a8cc713-4648-4623-aad1-7f297ac42978

More Info

expand_more

Published Date

2006

Language

Undefined/Unknown

Reuse Rights

Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.

Abstract

Theconstructionofgeneregulatorymodelsfrommicroarraytime-seriesdatahasreceivedmuchattention.Hereweproposeamethodthatextendsstandardcorrelationnetworkstoincorporateexplicittimeslices.Themethodisappliedtoatime-seriesdatasetofastudyongeneexpressioninthedevelopmentalphaseofzebra¿sh.Resultsshowthatthemethodisabletodistinguishrealrelationsbetweengenesfromthedata.Theserelationsareexplicitlyplacedintime,allowingforabetterunderstandingofgeneregulation.ThemethodanddatanormalisationprocedurehavebeenimplementedusingtheRstatisticallanguageandareavailablefromhttp://zebrafish.liacs.nl/supplements.html.