Expanding the Spectrum of Light-Driven Peroxygenase Reactions

Journal article (2019)

Authors

S.J. Willot BT/Biocatalysis - AS
E. Fernandez Fueyo BT/Biocatalysis - AS , BN/Greg Bokinsky Lab - AS
F. Tieves BT/Biocatalysis - AS
M. Pesic BT/Biocatalysis - AS
Miguel Alcalde Institute of Catalysis, CSIC, Madrid
I.W.C.E. Arends Universiteit Utrecht
Chan Beum Park Korea Advanced Institute of Science and Technology
F. Hollmann BT/Biocatalysis - AS
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2019 S.J. Willot, E. Fernandez Fueyo, F. Tieves, M. Pesic, Miguel Alcalde, I.W.C.E. Arends, Chan Beum Park, F. Hollmann
DOI: https://doi.org/10.1021/acscatal.8b03752
More Info
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Published Date

2019

Language

English

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

Peroxygenases require a controlled supply of H2O2 to operate efficiently. Here, we propose a photocatalytic system for the reductive activation of ambient O2 to produce H2O2 which uses the energy provided by visible light more efficiently based on the combination of wavelength-complementary photosensitizers. This approach was coupled to an enzymatic system to make formate available as a sacrificial electron donor. The scope and current limitations of this approach are reported and discussed.