Scale-spaces from protein networks

How diffusion profiles reveal functional information in physical interaction topologies

Poster (2012)

Authors

C Dimitrakopoulos University of Patras

M. Hulsman Pattern Recognition and Bioinformatics -

J. de Ridder Pattern Recognition and Bioinformatics -

Research Group

Pattern Recognition and Bioinformatics () (TU Delft)

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http://resolver.tudelft.nl/uuid:391406a7-4c0a-47cc-8bea-e12dfd8bd7a2

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Published Date

2012-3

Language

English

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Faculty

Electrical Engineering, Mathematics and Computer Science

Department

Intelligent Systems

Research Group

Pattern Recognition and Bioinformatics

Abstract

Summary

Understanding the living cell as a system of interconnected components is one of the key contemporary challenges. This is a complex problem, in which different types of functional interactions play a role, each operating across multiple distinct scales.

How do functional interactions emerge
from the topology of the physical interaction network?

To investigate this we explore scale independent descriptions of the topology of the physical protein-protein and protein-DNA interaction networks in yeast.