Amino Aldehydes Revisited

Mestrom, Luuk; Bracco, Paula; Hanefeld, U

Amino Aldehydes Revisited

Journal article (2017)

Authors

Luuk Mestrom BT/Biocatalysis

Paula Bracco BT/Biocatalysis

U Hanefeld BT/Biocatalysis

Research Group

BT/Biocatalysis

Oxidation Biocatalysis Enzymes Amino alcohols Amino aldehydes

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Published Date

22-12-2017

Language

English

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Research Group

BT/Biocatalysis

Abstract

The enzymatic oxidation of amino alcohols was studied to address the long-standing problem of product stability. Amino aldehydes, highly sought and unstable compounds, can be generated under mild conditions if they are immediately protected. Utilizing a range of alcohol dehydrogenases (ADHs) and semicarbazide as a scavenger, the enantioselective synthesis of protected amino aldehydes is possible. Glycerol dehydrogenase from Gluconobacter oxydans (GoGDH) displayed excellent enantioselectivity but limited substrate scope, whereas horse liver ADH catalyzed a broad range of conversions with low enantioselectivities.

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