Silicon based device for smart assessment of cellular stiffness

Master thesis (2017)

Authors

S. Kawasaki Electrical Engineering, Mathematics and Computer Science

Contributors

R. Dekker (mentor)
M.M. Kluba (mentor)
Faculty
Electrical Engineering, Mathematics and Computer Science, Electrical Engineering, Mathematics and Computer Science
Copyright: © 2017 Shinnosuke Kawasaki
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Published Date

07-11-2017

Language

English

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Faculty

Electrical Engineering, Mathematics and Computer Science

Abstract

Cellular stiffness plays an important role for several diseases such as atherosclerosis, malaria and cancer. Cellular stiffness can be derived by the velocity of a cell that is squeezed through a constriction channel. For example, a rigid cell will move slowly through the constriction channel and vice versa. In this research a microfluidic device with integrated electrodes was fabricated to detect the cell within the constriction channel. The velocity of the cell can be measured if the cell is detected at two different location. In this thesis the fabrication process of the device based on standard IC process is presented and electrically characterized.

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