Enantiospecific synthesis of tetrasubstituted δ-lactones

Journal article (1998)

Authors

Annabel L. Wilkinson University of Cambridge

U. Hanefeld University of Cambridge

Barrie Wilkinson University of Cambridge

Peter F. Leadlay University of Cambridge

James Staunton University of Cambridge

Affiliation

External organisation

Asymmetric synthesis Aldol reaction Lactones Combinatorial Biosynthesis Polyketides

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Published Date

1998

Language

English

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Abstract

For investigations concerning the selectivity of polyketide synthases (PKSs) which have been rationally engineered through genetic techniques the synthesis of substituted δ-lactones is of great importance. An enantiospecific route towards eight of the possible sixteen stereoisomers was developed which is also readily adaptable for the introduction of alkyl modifications and isotopic labels.