Multi-Processor Systems-on-Chips (MPSoCs) are the key enabler technology for current and future applications. However, the high on-chip connectivity, the programmability and IPs reusability, also introduce security concerns. Problems arise when applications with different trust and security levels share the MPSoC resources. One of the potent threats that MPSoCs see themselves exposed to are the so-called side-channel attacks (SCA). In this work, we explore the cache-based side-channel attacks optimized by the communication structure. We evaluate the vulnerability of the different NoC-based MPSoC memory configuration against micro-architectural side channel attacks. Our attack targets an MPSoC AES T-Table implementation. We explore the impact of the MPSoC organization on the NoC timing attack. We present the huge impact on the memory organization and present two attack metrics: efficacy and efficiency. Our results show that NoC-based MPSoCs are vulnerable and that deep memory hierarchies favor the security of the system.@en