This chapter presents a summary of the description and preliminary results of the use case related to the implementation of artificial intelligence tools in the emerging technology called wireless avionics intra-communications (WAICs). WAICs aims to replace some of the cable buses of modern aircraft. This replacement of infrastructure leads to: (1) complexity reduction of future airplanes, (2) creation of innovative services where wireless links are more flexible than wireline links, and mainly (3) a considerable weight reduction, which in turn leads to fuel consumption efficiency, increase of payload, as well as range extension. Therefore, WAICs is expected to have a large impact on the aeronautics industry, propelling a new generation of greener, more efficient, and less expensive aeronautical services. However, there are still several reliability, trust, interoperability and latency issues that need to be addressed before this technology becomes commercial. It is expected that AI will boost the applicability of this technology, contributing to the realization of the concept of “fly-by-wireless”.