This chapter discusses principles, frameworks, and steps for designing a roadmap to implement Responsible Research and Innovation (RRI) in industrial practices. It is based on invaluable experience gathered from the EU-funded PRISMA project, in which a trans-disciplinary group of experts from research, industries, and policy developed guidelines to include relevant societal values in the development strategy of innovative products. These guidelines are built on existing corporate social responsibility (CSR) and quality, risk and innovation management standards and policies. Fundamentally, they provide a management standard (Plan-Do-Check-Act cycle) that could help companies to introduce structural changes in their usual business practices toward more anticipatory, inclusive, and RRI practices (responsibility-by-design). The guidelines can be used by researchers, businesses, and innovators to develop long-term strategies (roadmaps) for Responsible Innovation, which, in turn, help organizations identify and achieve technologies geared toward ethically and socially desirable outcomes.