Climate induced damage in decorated oak wooden panels is considered to be a high risk for the preeminent museum collections. To advise museums on the development of future sustainable preservation strategies and to define rational guidelines for indoor climate specifications, climate induced physical and mechanical damage has been analysed in a collection study, experimental testing of mock-ups and by finite element modelling. The collection study consisted of the development of a comprehensive methodology to select objects of interest from the collection and analyse their condition using a combination of visual inspection and archival searches. Mock-up samples of wooden panels with representative structural elements were exposed to varying climate conditions in climate controlled rooms and monitored with state-of-the-art experimental mechanics equipment. Further the collection study and experimental testing were used to inform the development of a finite element model of crack growth under 3-point bending. The work was performed within the Cimate4Wood project, a multidisciplinary collaboration between conservators and scientists work. The paper presents the methodology of the museum study and results from the museum study, experimental testing and modelling.@en