The aerodynamic formation flight, which is also known as aircraft wake-surfing for efficiency (AWSE), enables aircraft to harvest the energy inherent in another aircraft’s wake vortex. As the thrust of the trailing aircraft can be reduced during cruise flight, the resulting benefit can be traded for longer flight time, larger range, less fuel consumption, or cost savings accordingly. Furthermore, as the amount and location of the emissions caused by the formation are subject to change and saturation effects in the cumulated wake of the formation can occur, AWSE can favorably affect the climate impact of the corresponding flights. In order to quantify these effects, we present an interdisciplinary approach combining the fields of aerodynamics, aircraft operations and atmospheric physics. The approach comprises an integrated model chain to assess the climate impact for a given air traffic scenario based on flight plan data, aerodynamic interactions between the formation members, detailed trajectory calculations as well as on an adapted climate model accounting for the saturation effects resulting from the proximity of the emissions of the formation members. Based on this approach, we derived representative AWSE scenarios for the world’s major airports by analyzing and assessing flight plans. The resulting formations were recalculated by a trajectory calculation tool and emission inventories for the scenarios were created. Based on these inventories, we quantitatively estimated the climate impact using the average temperature response (ATR) as climate metric, calculated as an average global near surface temperature change over a time horizon of 50 years. It is shown, that AWSE as a new operational procedure has a significant mitigation potential on climate impact. For a global formation flight scenario, we estimated the average relative change of climate response to range between 22% and 24% while the relative fuel saving effects sum up to 5-6%.