Recent and past observations of chemical and physical peculiarities in the atmosphere of Venus have renewed speculations about the existence of life in its clouds. To find signs of Venusian life, a dedicated astrobiological space exploration mission is required, and for this reason the Venus Life Finder mission is currently being prepared. A Venus Life Finder mission will require dedicated and specialized instruments to hunt for biosignatures and habitability indicators. In this contribution, we present the ORIGIN space instrument, a laser desorption/laser ablation ionization mass spectrometer. This instrument is designed to detect large, non-volatile molecules, specifically biomolecules such as amino acids and lipids. At the same time, it can also be used in ablation mode for elemental composition analysis. Recent studies with this space prototype instrument of amino acids, polycyclic aromatic hydrocarbons, lipids, salts, metals, sulphur isotopes, and microbial elemental composition are discussed in the context of studies of biosignatures and habitability indicators in Venus’s atmosphere. The implementation of the ORIGIN instrument into a Venus Life Finder mission is discussed, emphasizing the low weight and low power consumption of the instrument. An instrument design and sample handling system are presented that make optimal use of the capabilities of this instrument. ORIGIN is a highly versatile instrument with proven capabilities to investigate and potentially resolve many of the outstanding questions about the atmosphere of Venus and the presence of life in its clouds.

In the search for extraterrestrial life, biosignatures (e.g., organic molecules) play an important role, of which lipids are one considerable class. If detected, these molecules can be strong indicators of the presence of life, past or present, as they are ubiquitous in life on Earth. However, their detection is challenging, depending on, e.g., instrument performance, as well as the selected site. In this contribution, we demonstrate that, using laser desorption ionization mass spectrometry, detection of lipids is feasible. Using our space prototype instrument designed and built in-house, six representative lipids were successfully detected: cholecalciferol, phylloquinone, menadione, 17α-ethynylestradiol, α-tocopherol, and retinol, both as pure substances and as mixtures additionally containing amino acids or polycyclic aromatic hydrocarbons. Observed limits of detection for lipids already meet the requirements stated in the Enceladus Orbilander mission concept. The current performance of our LDI-MS system allows for the simultaneous identification of lipids, amino acids, and polycyclic aromatic hydrocarbons, using a single instrument. We therefore believe that the LDI-MS system is a promising candidate for future space exploration missions devoted to life detection.

Spectroscopic instruments were a part of payloads on orbiter and lander missions and delivered vast data sets to explore minerals, elements and molecules on air-less rocky planets, asteroids and comets on global and local scales. To answer current space science questions, the chemical composition of planetary rocks and soils at grain scale is required, as well as measurements of element (isotope) concentrations down to the part per million or lower. Only mass spectrometric methods equipped with laser sampling ion sources can deliver the necessary information. Laser sampling techniques can reduce the dimensions of the investigated sample material down to micrometre scale, allowing for the composition analysis of grain-sized objects or thin mineral layers with sufficiently high spatial resolution, such that important geological processes can be recognised and studied as they progressed in time. We describe the performance characteristics, when applied to meteorite and geological samples, of a miniaturised laser ablation/ionisation mass spectrometer (named LMS) system that has been developed in our group. The main advantages of the LMS instrument over competing techniques are illustrated by examples of high spatial (lateral and vertical) resolution studies in different meteorites, terrestrial minerals and fossil-like structures in ancient rocks for most elements of geochemical interest. Top-level parameters, such as dimension, weight, and power consumption of a possible flight design of the LMS system are presented as well.