This conceptual and exploratory research study investigates, systematically and holistically, climate-adaptive spatial design interventions for high-density informal urban areas in hot arid climates, which remain understudied despite their vulnerability to heat stress and the heat-vulnerable groups populating them. Five streetscape design prototypes are proposed that include climate-adaptive spatial interventions appraised qualitatively with consideration to relevant feasibility matters: land use planning, equity, affordability, mobility, and sense of place. The study shows that there is potential for climate-adaptive interventions in informal urban areas in hot arid climates, but that these interventions also present challenges. Common climate-adaptive design strategies can be used to address heat stress in these areas but, for example, increasing vegetation might be challenging due to water stress. As a conceptual study, the findings presented and the discussion raised on feasibility are targeted at opening avenues for future research, and at informing decision-makers and spatial designers.