Acetic acid is an essential chemical used in the production of many chemical products. Using methanol as bio-building block, the acetic acid produced may be incorporated in bio-based products. This study deals with enhancing the efficiency of separations in a process using a homogeneous catalyst, which is the most applied today industrially. Several configurations for downstream processing by distillation are investigated using effective combinations of fully thermally coupled columns, namely, dividing-wall columns, alone or combined with heat pumps. The results indicate that the three-column direct sequence may be effectively replaced by a two-column sequence. Overall, the total annual cost is reduced by 34 %. The cost of compressor may be paid back in 1.5 years by the saved energy. Low energy intensity is achieved by tight integration with the reaction section.